Kresge Hearing Research Institute - Otopathology Laboratory

Protection, repair and regeneration of the inner ear

The Kresge Hearing Research Institute was founded in 1963 in order to gain a better understanding of hearing and deafness.

Richard A. Altschuler, Ph.D.
Jochen Schacht, Ph.D.
Susan E. Shore, Ph.D.
David F. Dolan, Ph.D.
Bryan E. Pfingst, Ph.D.
Thomas E. Carey, Ph.D.
John C. Middlebrooks, Ph.D.
Glenn E. Green, M.D.
Josef M. Miller, Ph.D.
Keith Duncan, Ph.D.
Marci M. Lesperance, M.D.
Margaret I. Lomax, Ph.D.
David C. Kohrman, Ph.D.
Su-Hua Sha, M.D.
Yehoash Raphael, Ph.D.
W. Michael King, Ph.D.

1301 East Ann Street
Ann Arbor, MI 48109-0506
USA
Phone: +1-734-764-8110
Fax: +1-734-764-0014

The tissue engineering programme at KHRI comprises physiology, psychophysics, electrical engineering, morphology, material sciences, genetics, cell biology and molecular biology.

Dr. Josef M. Miller, Director of the Cochlear Signals and Tissue Engineering Lab, focuses on the understanding of basic mechanisms of protection and tissue repair and recovery of the traumatised cochlea.

Dr. Yehoash Raphael, Head of the Otopathology Laboratory, is investigating the transdifferentiation of non-sensory supporting cells into hair cells as it is standard in birds or other non-mammals. His research group has induced transdifferentiation by insertion of the gene Atoh1, a gene known to be involved in hair cell differentiation.